For two decades, researchers debated whether adeno-associated viruses (AAVs), the small viruses used to deliver new genes into thousands of patients, could in certain cases drive tumors. That debate is over. A series of cases this year has presented powerful evidence that AAVs can cause cancer, forcing researchers and families to weigh the newly confirmed risk against the technology’s life-saving potential — and hopefully determine how to design better therapies in the future. “It will change the calculus for some patients,” said Sam Mackenzie, a neurologist at University of Rochester, speaking specifically about spinal muscular atrophy patients. Continue to STAT+ to read the full story…
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